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Animal
Mouse
Startle/PPI Test Multiple-cage Set-Up for Mice
Product Code:48163/48263/48463
Category: Behaviour, Conditioning, Reward
Automatic detection of the startle reflex (pre-pulse inhibition PPI) in mice. Particularly for research into psychiatric disorders, drug use and more.
Customizable, complete set up, ready to go. Includes controller, Startle Link-Box, Isolation Cubicles, Stimulating/Recording Platform.
Background
- The startle response (PPI) is a largely unconscious defensive response to sudden or threatening stimuli, such as sudden noise or sharp movement, and is associated with a negative effect. Startle stimuli are usually acoustic. Tactile stimuli and light-based stimuli are also used.
- Deficits of PPI have been linked to abnormalities of sensorimotor gating, often in patients with psychiatric disorders such as Schizophrenia and Alzheimer’s Disease, or under the influence of drugs, surgical manipulations, mutations or elderly.
- Animal models are widely used to test hypotheses linking genetic components of various diseases with sensorimotor gating.
Complete set up, ready to go
- Automatic detection of Startle Reflex in mice
- Complete set up, ready to start your tests. Customizable to suit your needs. A typical system combines the following elements:
- Dedicated Software
- Startle Link-Box (collects and conveys signals to Controller)
- Up to 4 Isolation Cubicles that includes an infrared (I.R.) light, a loudspeaker and a noiseless fan, all conveniently positioned inside the sound attenuating box
- Stimulating/Recording (S/R) Platform (includes the light, speaker and detection system)
- 2 Animal Boxes – large and small (no holder)
- Flexible testing, easy to set up. Simply define trial number, sound and light stimulus and timing of experimental sequences (all fully randomizable):
- Pulse
- Pre-pulse
- Inter-Pulse Interval
- Inter-Stimulus Interval
- Add multiple cages using expansion-cubicle/s featuring slave electronics.
- Connects to the flexible, cost effective beehive cage-manager system. Use one touch screen controller to control and manage all of your Ugo Basile cages. Ask for details!
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Features | Benefits |
|---|---|
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Maximum Flexibility, full event randomization |
Configure your own Experimental Schedules directly on your PC |
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User-friendly software included |
Exceptional flexibility and intuitivity in the software protocol building |
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Great Versatility |
The same controller can manage different conditioning tests. Ask for details! |
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General | |
|---|---|
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Power Requirements |
Universal input 100-240 VAC, 50-60Hz, 60W |
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Sound Level + Whitenoise |
< 60 dB |
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Operating environment |
10°C to 40°C; 5% to 95% RH (non-condensing) |
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Operation | |
| Sound Range |
From 65 dB to 120 dB |
| Pulse/pre pulse sound range (at 3KHz) | From 65 dB to 120 dB |
| Modulated Sound Frequency Range | From 100 Hz to 18 KHz |
| Airpuff |
Air Puff stimulus complete system add-on |
| IR Light |
0-100% (Environment) |
| Flash Light |
0-100% (20K Lux) S/R Platform) |
| Data Export |
.csv, .xlsx format |
| Number of cages | Up to 4 |
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Physical | |
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Dimensions |
25(d)x33(w)x5.5(h)cm (40500-001) |
| Internal Dimensions |
Small Mouse: ID 84x34x39(h)mm Large Mouse: ID 84x39x44(h)mm |
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Weight |
2.7Kg |
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Shipping Weight |
Mouse Single-Cage Set-Up: 40Kg |
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Packing Dimensions |
82x71x57cm (wooden crate) for a Mouse Single-Cage Set-up |
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Warranty | |
| Warranty | Startle PPI is covered by a 12-month warranty + 12 after product registration |
| UB-Care | Additional UB-Care can be added for other 12 or 24 months |
In animals, including humans, the startle response is a largely unconscious defensive response to sudden or threatening stimuli, such as sudden noise or sharp movement, and is associated with negative effect. Usually the onset of the startle response is a startle reflex reaction, a brainstem reflectory reaction (reflex) that serves to protect vulnerable parts, such as the back of the neck (whole-body startle) and the eyes (eyeblink) and facilitates escape from sudden stimuli.
Prepulse Inhibition (PPI) is a neurological phenomenon in which a weaker prestimulus (prepulse) inhibits the reaction of an organism to a subsequent strong startling stimulus (pulse). The stimuli are usually acoustic, but tactile stimuli (e.g. via air puffs on the skin) and light stimuli are also used.
The reduction of the amplitude of startle reflects the ability of the nervous system to temporarily adapt to a strong sensory stimulus when a preceding weaker signal is given to warn the organism.
Deficits of prepulse inhibition, manifesting in the inability to filter out the unnecessary information, have been linked to abnormalities of sensorimotor gating, noted in patients suffering from illnesses like Schizophrenia and Alzheimer’s Disease, or under the influence of drugs, surgical manipulations, or mutations. Animal models are widely used to test hypotheses linking genetic components of various diseases with sensorimotor gating.
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48153 Startle/PPI System for Mice, single cage system | ||
|---|---|---|
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40500-001 |
Controller with Touch Screen and 8-pole Scrambling Shocker |
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48005 |
Stimulating/Recording Platform for Mouse |
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48000-320 |
Small Mouse Box |
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48000-322 |
Large Mouse Box |
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48000-100 |
Startle link-box |
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46000-590 |
Isolation Cubicle, sound attenuation box with IR Light, loudspeaker, noiseless fan |
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52010-323 |
USB pen-drive, including |
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48253 STARTLE/PPI SYSTEM FOR MICE, two-cage system | ||
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40500-001 |
Controller with Touch Screen and 8-pole Scrambling Shocker |
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48005 |
Stimulating/Recording Platform for Mouse |
|
|
48000-320 |
Small Mouse Box |
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48000-322 |
Large Mouse Box |
|
|
48000-100 |
Startle link-box |
|
|
46000-590 |
Isolation Cubicle, sound attenuation box with IR Light, loudspeaker, noiseless fan |
|
|
52010-323 |
USB pen-drive, including |
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48453 STARTLE/PPI SYSTEM FOR MICE, four-cage system | ||
|
40500-001 |
Controller with Touch Screen and 8-pole Scrambling Shocker |
|
|
48005 |
Stimulating/Recording Platform for Mouse |
|
|
48000-320 |
Small Mouse Box |
|
|
48000-322 |
Large Mouse Box |
|
|
48000-100 |
Startle link-box |
|
|
46000-590 |
Isolation Cubicle, sound attenuation box with IR Light, loudspeaker, noiseless fan |
|
|
52010-323 |
USB pen-drive |
|
M. Koch: “The Neurobiology of Startle” Prog Neurobiol. 59(2):107-28, 1999
D. Braff et alia: “Human Studies of Prepulse Inhibition of Startle: Normal Subjects, Patient Groups, and Pharmacological Studies” Psychopharmacology 156(2): 234-258., 2001
H.S. Hoffman et al.: “Startle Reaction: Modification By Background Acoustic Stimulation” Science 141: 928-30, 1963
R.R. Marsh et alia: “The Role of Small Changes in the Acoustic Environment in Modifying the Startle Reflex” J Exp Psychol Anim Behav Process, 1(3): 1975